Old blood can prematurely age the brains of young mice, and scientists may now be closer to understanding how. A protein located in the cells that form a barrier between the brain and blood could be partly to blame, experiments on mice suggest.
If something similar happens in humans, scientists say, methods for countering the protein may hold promise for treating age-related brain decline.
The preliminary study, published online January 3 at bioRxiv.org, focused on a form of the protein known as VCAM1, which interacts with immune cells in response to inflammation. As mice and humans age, levels of that protein circulating in the blood rise, Alzheimer researcher Tony Wyss-Coray at Stanford University and colleagues found. After injecting young mice behind an eye with plasma from old mice, the team discovered that VCAM1 levels also rose in certain parts of the blood-brain barrier, a mesh of tightly woven cells that protect the brain from harmful factors in the blood. The young mice showed signs of brain deterioration as well, including inflammation and decreased birthrates of new nerve cells. Plasma from young mice had no such effects.
Interfering with VCAM1 may help prevent the premature aging of brains. Plasma from old mice didn’t have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood-brain barrier cells. Nor did it affect mice treated with antibodies that blocked the activity of VCAM1. Those antibodies also seemed to help the brains of older mice that had aged naturally, the team found.
The results suggest that anti-aging treatments targeting specific aspects of the blood-brain barrier may hold promise.
These fins were made for walking, and that’s just what these fish do — thanks to wiring that evolved long before vertebrates set foot on land.
Little skates use two footlike fins on their undersides to move along the ocean floor. With an alternating left-right stride powered by muscles flexing and extending, the movement of these fish looks a lot like that of many land-based animals.
Now, genetic tests show why: Little skates and land vertebrates share the same genetic blueprint for development of the nerve cells needed for limb movement, researchers report online February 8 in Cell. This work is the first to look at the origins of the neural circuitry needed for walking, the authors say. “This is fantastically interesting natural history,” says Ted Daeschler, a vertebrate paleontologist at the Academy of Natural Sciences in Philadelphia.
“Neurons essential for us to walk originated in ancient fish species,” says Jeremy Dasen, a neuroscientist at New York University. Based on fossil records, Dasen’s team estimates that the common ancestor of all land vertebrates and skates lived around 420 million years ago — perhaps tens of millions of years before vertebrates moved onto land (SN: 1/14/12, p. 12). Little skates (Leucoraja erinacea) belong to an evolutionarily primitive group. Skates haven’t changed much since their ancestors split from the fish that evolved into land-rovers, so finding the same neural circuitry in skates and land vertebrates was surprising.
The path to discovery started when Dasen and coauthor Heekyung Jung, now at Stanford University, saw YouTube videos of the little skates walking.
“I was completely flabbergasted,” Dasen says. “I knew some species of fish could walk, but I didn’t know about these.”
Most fish swim by undulating their bodies and tails, but little skates have a spine that remains relatively straight. Instead, little skates move by flapping pancake-shaped pectoral fins and walking on “feet,” two fins tucked along the pelvis.
Measurements of the little skates’ movements found that they were “strikingly similar” to bipedal walking, says Jung, who did the work while at NYU. To investigate how that similarity arose, the researchers looked to motor nerve cells, which are responsible for controlling muscles. Each kind of movement requires different kinds of motor nerve cells, Dasen says.
The building of that neural circuitry is controlled in part by Hox genes, which help set the body plan, where limbs and muscles and nerves should go. For instance, snakes and other animals that have lost some Hox genes have bodies that move in the slinky, slithery undulations that many fish use to swim underwater.
By comparing Hox genes in L. erinacea and mice, researchers discovered that both have Hox6/7 and Hox10 genes and that these genes have similar roles in both. Hox6/7 is important for the development of the neural circuitry used to move the skates’ pectoral fins and the mice’s front legs; Hox10 plays the same role for the footlike fins in little skates and hind limbs in mice. Other genes and neural circuitry for motor control were also conserved, or unchanged, between little skates and mice. The findings suggest that both skates and mice share a common ancestor with similar genetics for locomotion.
The takeaway is that “vertebrates are all very similar to each other,” says Daeschler. “Evolution works by tinkering. We’re all using what we inherited — a tinkered version of circuitry that began 400-plus million years ago.”
Orangutan numbers on the Southeast Asian island of Borneo plummeted from 1999 to 2015, more as a result of human hunting than habitat loss, an international research team finds.
Over those 16 years, Borneo’s orangutan population declined by about 148,500 individuals. A majority of those losses occurred in the intact or selectively logged forests where most orangutans live, primatologist Maria Voigt of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and colleagues report February 15 in Current Biology. “Orangutan killing is likely the number one threat to orangutans,” says study coauthor Serge Wich, a biologist and ecologist at Liverpool John Moores University in England. Humans hunt the forest-dwelling apes for food, or to prevent them from raiding crops, the investigators say. People also kill adult orangutans to steal their babies for the international pet trade.
Between 70,000 and roughly 100,000 orangutans currently live on Borneo, Wich says. That’s substantially higher than previous population estimates. The new figures are based on the most extensive survey to date, using ground and air monitoring of orangutans’ tree nests. Orangutans live only on Borneo and the island of Sumatra and are endangered in both places.
Still, smaller orangutan populations in deforested areas of Borneo — due to logging or conversion to farm land — experienced the severest rates of decline, up to a 75 percent drop in one region.
Satellite data indicate that Borneo’s forest area has already declined by about 30 percent from 1973 to 2010. In the next 35 years, Voigt’s team calculates that further habitat destruction alone will lead to the loss of around 45,000 more of these apes. “Add hunting to that and it’s a lethal mix,” Wich says. But small groups of Bornean orangutans living in protected zones and selectively logged areas will likely avoid extinction, the researchers say.
While the drama of human heart transplants has grasped the public interest, kidney transplants are ahead in the field…. Although only three little girls are now surviving liver transplants, the liver is a promising field for replacement…. The donor, of course, must be dead; no one can live without his liver. — Science News, March 2, 1968
Update Kidney patients, who could receive organs from family members, had up to a 75 percent one-year survival rate in 1968. Liver recipients were less lucky, having to rely on unrelated, postmortem donations. Liver patients’ immune systems often attacked the new organ and one-year survival was a low 30 percent. Cyclosporine, an immune-suppressing drug available since 1983, has made a big difference. Now, about 75 percent of adults are alive three years after surgery, and children’s odds are even better. The liver is still a must-have organ, and the need for donor livers has climbed. Today, the options have expanded, with split-liver transplants and partial transplants from living donors.
A new type of battery can stand being left out in the cold.
This rechargeable battery churns out charge even at –70° Celsius, a temperature where the typical lithium-ion batteries that power many of today’s cell phones, electric cars and other devices don’t work. Batteries that withstand such frigid conditions could help build electronics that function in some of the coldest places on Earth or on space rovers that cruise around other planets.
Inside lithium-ion batteries, ions flow between positive and negative electrodes, where the ions are embedded and then released to travel back through a substance called an electrolyte to the other end. As the temperature drops, the ions move sluggishly through the electrolyte. The cold also makes it harder for ions to shed the electrolyte material that gloms onto them as they cross the battery. Ions must slough off the matter to fit into the electrode material, explains study coauthor Xiaoli Dong, a battery researcher at Fudan University in Shanghai. Such cold conditions make conventional lithium-ion batteries less effective. At –40° C, these batteries deliver about 12 percent of the charge they do at room temperature; at –70° C, they don’t work at all.
The new battery, described online February 28 in Joule, contains a special kind of electrolyte that allows ions to flow easily between electrodes even in the bitter cold. The researchers also fitted their battery with electrodes made of organic compounds, rather than the typical transition-metal-rich materials. Ions can lodge themselves in this organic material without having to strip off the electrolyte material stuck to them. So these organic electrodes catch and release ions more easily than electrodes in normal batteries, even at low temps, Dong says.
Because the ions flow better and connect more readily with the electrodes at lower temperatures, the battery retains about 70 percent of its room-temperature charging capacity even at –70° C. Still, battery cells in the new design pack less energy per gram than standard lithium-ion batteries, says Shirley Meng, a materials scientist at the University of California, San Diego, not involved in the work. She would like to see whether a more energy-dense version of the battery can be built.
LOS ANGELES — Insights into a black hole paradox may come from a down-to-Earth source.
Superconductors, materials through which electrons can move freely without resistance, may share some of the physics of black holes, physicist Sreenath Kizhakkumpurath Manikandan of the University of Rochester in New York reported March 7 at a meeting of the American Physical Society. The analogy between the two objects could help scientists understand what happens to information that gets swallowed up in a black hole’s abyss. When a black hole gobbles up particles, information about the particles’ properties is seemingly trapped inside. According to quantum mechanics, such information cannot be destroyed. Physicist Stephen Hawking determined in 1974 that black holes slowly evaporate over time, emitting what’s known as Hawking radiation before eventually disappearing. That fact implies a conundrum known as the black hole information paradox (SN: 5/31/14, p. 16): When the black hole evaporates, where does the information go?
One possible solution, proposed in 2007 by physicists Patrick Hayden of Stanford University and John Preskill of Caltech, is that the black hole could act like a mirror, with information about infalling particles being reflected outward, imprinted in the Hawking radiation. Now, Manikandan and physicist Andrew Jordan, also of the University of Rochester, report that a process that occurs at the interface between a metal and a superconductor is analogous to the proposed black hole mirror.
The effect, known as Andreev reflection, occurs when electrons traveling through a metal meet a superconductor. The incoming electron carries a quantum property known as spin, similar to the spinning of a top. The direction of that spin is a kind of quantum information. When the incoming electron meets the superconductor, it pairs up with another electron in the material to form a duo known as a Cooper pair. Those pairings allow electrons to glide easily through the material, facilitating its superconductivity. As the original electron picks up its partner, it also leaves behind a sort of electron alter ego reflecting its information back into the metal. That reflected entity is referred to as a “hole,” a disturbance in a material that occurs when an electron is missing. That hole moves through the metal as if it were a particle, carrying the information contained in the original particle’s spin.
Likewise, if black holes act like information mirrors, as Hayden and Preskill suggested, a particle falling into a black hole would be followed by an antiparticle coming out — a partner with the opposite electric charge — which would carry the information contained in the spin of the original particle. Manikandan and Jordan showed that the two processes were mathematically equivalent. It’s still not clear whether the black hole mirror is the correct solution to the paradox, but the analogy suggests experiments with superconductors could clarify what happens to the information, Jordan says. “That’s something you can’t ever do with black holes: You can’t do those detailed experiments because they’re off in the middle of some galaxy somewhere.”
The theory is “intriguing,” says physicist Justin Dressel of Chapman University in Orange, Calif. Such comparisons are useful in allowing scientists to take insights from one area and apply them elsewhere. But additional work is necessary to determine how strong an analogy this is, Dressel says. “You may find with further inspection the details are different.”
THE WOODLANDS, Texas — A new map of flat, light-colored streaks and splotches on the moon links the features to a few large impacts that spread debris all over the surface. The finding suggests that some of the moon’s history might need rethinking.
Planetary scientist Heather Meyer, now at the Lunar and Planetary Institute in Houston, used data from NASA’s Lunar Reconnaissance Orbiter to make the map, the most detailed global look at these light plains yet. Previous maps had been patched together from different sets of observations, which made it hard to be sure that features that looked like plains actually were. Astronomers originally assumed that the light plains were ancient lava flows from volcanoes. But rocks brought back from one of these plains by Apollo 16 astronauts in 1972 did not have volcanic compositions. That finding led some scientists to suspect the plains, which cover about 9.5 percent of the lunar surface, came from giant impacts.
Meyer’s map supports the impact idea. Most of the plains, which are visible across the whole moon, seem to originate from debris spewed from the Orientale basin, a 930-kilometer-wide bowl in the moon’s southern hemisphere that formed about 3.8 billion years ago. “It looks like there’s just a giant splat mark,” Meyer says. About 70 percent of the lunar plains come from either Orientale or one other similar basin, she reported March 22 at the Lunar and Planetary Science Conference. “What this is telling us,” she says, “is these large basins modified the entire lunar surface at some point.” The map also shows that some small impact craters up to 2,000 kilometers from Orientale have been filled in with plains material. That’s potentially problematic, because planetary scientists use the number of small impact craters to estimate the age of the lunar surface. If small craters have been erased by an impact half a moon away, that could mean some of the surface is older than it looks, potentially changing scientists’ interpretations of the moon’s history (SN: 6/11/16, p. 10).
China’s first space station, Tiangong-1, is expected to fall to Earth sometime between March 31 and April 1. No fooling.
Most of the 10.4-meter-long station will burn up as it zooms through Earth’s atmosphere. But some parts will survive and reach the ground, according to the European Space Agency’s Space Debris Office. No one can be sure where or when those pieces will hit. Even within hours of the station reaching the atmosphere, the final hit zone predictions will cover thousands of kilometers. ESA predicts that any latitude between 42.8° N (so as far north as Chicago) and 42.8° S (down to Tasmania) is fair game. The geometry of the station’s orbit means that the edges of that zone are more likely to be hit than the equator. Much of that area is oceans or uninhabited. “The personal probability of being hit by a piece of debris from Tiangong-1 is actually 10 million times smaller than the yearly chance of being hit by lightning,” according to ESA. (If you’re wondering, the annual chance of getting zapped in the United States is 1 in 1,083,000.) Launched in 2011, Tiangong-1 — which means Heavenly Palace — was visited twice by Chinese astronauts, in 2012 and in 2013. The craft was supposed to last only two years, and China put it into sleep mode after the second visit to prepare to steer it back to Earth for a controlled reentry. But in March 2016, the Chinese space agency announced that they had lost contact with the craft and expected it to reenter the atmosphere sometime in 2017 Reentry is unlikely to be dangerous, but it will look cool. The disintegrating space station will blaze through the sky like a fireball. ESA and the Chinese space agency are running daily updates on the station’s location, so check back to see if it will be visible where you are.
PHOENIX — A new, breathable material that can also block biological or chemical threats could offer comfortable protection for people working in contaminated environments or dangerous military zones.
The bottom layer of the material, described April 3 at the Materials Research Society spring meeting, features carbon nanotube pores embedded within a flexible synthetic polymer film. These pores are just a few nanometers across — too small for bacterial or viral cells to squeeze through, but wide enough for sweat to escape. The top layer offers further protection. It is made of another, spongy polymer that normally allows water and other molecules to pass through. But when the polymer comes into contact with G-series nerve agents — the family of toxic chemicals that includes sarin gas — it flattens into a dense sheet that seals over the carbon nanopores underneath. The polymer can be restored to its original state by soaking it in a high-pH chemical broth.
Both layers together are still less than half the thickness of a sheet of paper, and could be laid over fabrics without putting the wearer at risk of overheating. That’s an improvement over the typical protective gear that’s permanently sealed against contaminants, said study coauthor Francesco Fornasiero, a chemical engineer at Lawrence Livermore National Laboratory in California.
In early testing, the material completely blocked out dengue virus cells, as well as 90 percent of the chemical diethyl chlorophosphate, used as a stand-in for toxic nerve agents. The researchers are working to make the material even more impervious to dangerous chemicals, Fornasiero said.
About 50 million years ago, a monitor lizard in what is now Wyoming perceived the world through four eyes. Saniwa ensidens is the only known jawed vertebrate to have had two eyelike photosensory structures at the top of the head, in addition to the organs we commonly think of as eyes, researchers report April 2 in Current Biology.
The structures are called the pineal and parapineal organs. Among animals alive today, only the jawless fish called a lamprey has both structures. But many modern reptiles have a so-called third eye, the pineal organ. The researchers examined fossils collected 150 years ago by Yale University students. Scans of the fossils using a technique called X-ray computed tomography revealed spaces in the skull for both the third and fourth eye.
What the ancient lizard did with these organs isn’t known, but some modern vertebrates use the amplified photosensitivity they glean from the pineal glands to navigate. S. ensidens may have been able to perceive polarized light and use the angle of the sun like a compass, as some modern lizards do. Or it may have navigated using Earth’s magnetic field, much like some amphibians and migratory birds.
