Two New York researchers have found the hallucinogenic drug will markedly increase the rate of abnormal change in chromosomes. [Scientists] tested LSD on cell cultures from the blood of two healthy individuals … [and] also found similar abnormal changes in the blood of a schizophrenic patient who had been treated with [LSD]. The cell cultures showed a two-fold increase in chromosomal breaks over the normal rate. — Science News, April 1, 1967
Update Psychedelic-era reports that LSD damages chromosomes got lots of press but fell apart within a few years. A review in Science in 1971 concluded that ingesting moderate doses of LSD caused no detectable genetic damage. Researchers are still trying to figure out the molecular workings of the drug. Recent evidence suggests that the substance gets trapped in a pocket of the receptor for serotonin, a key chemical messenger in the brain. Its prolonged stay may explain why LSD trips can last up to a day or more (SN: 3/4/17, p. 16).
Neandertals knew how to kick it up a couple of notches. Between 38,000 and 43,000 years ago, these close evolutionary relatives of humans added two notches to five previous incisions on a raven bone to produce an evenly spaced sequence, researchers say.
This visually consistent pattern suggests Neandertals either had an eye for pleasing-looking displays or saw some deeper symbolic meaning in the notch sequence, archaeologist Ana Majkić of the University of Bordeaux, France, and her colleagues report March 29 in PLOS ONE.
Notches added to the bone, unearthed in 2005 at a Crimean rock shelter that previously yielded Neandertal bones, were shallower and more quickly dashed off than the original five notches. But additions were carefully placed, resulting in relatively equal spacing of all notches.
Although bone notches may have had a practical use, such as fixing thread on an eyeless needle, the even spacing suggests Neandertals had a deeper meaning in mind — or at least knew what looked good.
Previous discoveries suggest Neandertals made eagle-claw necklaces and other personal ornaments, possibly for use in rituals (SN: 4/18/15, p. 7).
The Milky Way’s black hole may finally get its close-up.
Beginning on April 5, scientists with the Event Horizon Telescope will attempt to zoom in on a never-before-imaged realm: a black hole’s event horizon. That’s the boundary at which gravity’s pull becomes so strong that nothing can escape.
In the telescope’s cross hairs are two supermassive black holes, one at the center of the Milky Way, the other in the nearby galaxy M87. Scientists hope to capture the light emitted by a halo of gas that swirls just outside the event horizon as the black hole swallows it up.
The Event Horizon Telescope is not one telescope, but eight radio observatories linked together into a massive network that spans the globe. The new observations will be the first that include the ultrasensitive Atacama Large Millimeter/submillimeter Array in Chile’s Atacama Desert, increasing the possibility that the image will reveal new details. Astronomers will take data for five nights within a 10-day period.
This is no Polaroid picture, though — it will be months before the data have been crunched and the portrait is ready for prime time.
Sometimes it seems like every year offers an occasion to celebrate some sort of Einstein anniversary.
In 2015, everybody lauded the 100th anniversary of his general theory of relativity. Last year, scientists celebrated the centennial of his prediction of gravitational waves — by reporting the discovery of gravitational waves. And this year marks the centennial of Einstein’s paper establishing the birth of modern cosmology.
Before Einstein, cosmology was not very modern at all. Most scientists shunned it. It was regarded as a matter for philosophers or possibly theologians. You could do cosmology without even knowing any math.
But Einstein showed how the math of general relativity could be applied to the task of describing the cosmos. His theory offered a way to study cosmology precisely, with a firm physical and mathematical basis. Einstein provided the recipe for transforming cosmology from speculation to a field of scientific study.
“There is little doubt that Einstein’s 1917 paper … set the foundations of modern theoretical cosmology,” Irish physicist Cormac O’Raifeartaigh and colleagues write in a new analysis of that paper.
Einstein had pondered the implications of his new theory for cosmology even before he had finished it. General relativity was, after all, a theory of space and time — all of it. Einstein’s showed that gravity — the driving force sculpting the cosmic architecture — was simply the distortion of spacetime geometry generated by the presence of mass and energy. (He constructed an equation to show how spacetime geometry, on the left side of the equation, was determined by the density of mass-energy, the right side.) Since spacetime and mass-energy account for basically everything, the entire cosmos ought to behave as general relativity’s equation required.
Newton’s law of gravity had posed problems in that regard. If every mass attracted every other mass, as Newton had proclaimed, then all the matter in the universe ought to have just collapsed itself into one big blob. Newton suggested that the universe was infinite, filled with matter, so that attraction inward was balanced by the attraction of matter farther out. Nobody really bought that explanation, though. For one thing, it required a really precise arrangement: One star out of place, and the balance of attractions disappears and the universe collapses. It also required an infinity of stars, making it impossible to explain why it’s dark at night. (There would be a star out there along every line of sight at all times.)
Einstein hoped his theory of gravity would resolve the cosmic paradoxes of Newtonian gravity. So in early 1917, less than a year after his complete paper on the general theory was published, he delivered a short paper to the Prussian Academy of Sciences outlining the implications of his theory for cosmology. In that paper, titled “Cosmological Considerations in the General Theory of Relativity,” he started by noting the problems posed by using Newton’s gravity to describe the universe. Einstein showed that Newton’s gravity would require a finite island of stars sitting in an infinite space. But over time such a collection of stars would evaporate. That problem could be avoided, though, if the universe turned out not to be infinite. Instead, Einstein said, everything would be fine if the universe is finite. Big, sure, but curved in such a way that it closed on itself, like a sphere.
Einstein’s mathematical challenge was to show that such a finite cosmic spacetime would be static and stable. (In those days nobody knew that the universe was expanding.) He assumed that on a large enough scale, the distribution of matter in this universe could be considered uniform. (Einstein said it was like viewing the Earth as a smooth sphere for most purposes, even though its terrain is full of complexities on smaller distance scales.) Matter’s effect on spacetime curvature would therefore be pretty much constant, and the universe’s overall condition would be unchanging.
All this made sense to Einstein because he had a limited view of what was actually going on in the cosmos. Like many scientists in those days, he believed the universe was basically just the Milky Way galaxy. All the known stars moved fairly slowly, consistent with his belief in a spherical cosmos with uniformly distributed mass. Unfortunately, general relativity’s math didn’t work if that was the case — it suggested the universe would not be stable. Einstein realized, though, that his view of the static spherical universe would succeed if he added a term to his original equation.
In fact, there were good reasons to include the term anyway. O’Raifeartaigh and colleagues point out that in his earlier work on general relativity, Einstein remarked in a footnote that his equation technically permitted the inclusion of an additional term. That didn’t seem to matter at the time. But in his cosmology paper, Einstein found that it was just the thing his equation needed to describe the universe properly (as Einstein then supposed the universe to be). So he added that factor, designated by the Greek letter lambda, to the left-hand side of his basic general relativity equation.
“That term is necessary only for the purpose of making possible a quasi-static distribution of matter, as required by the fact of the small velocities of the stars,” Einstein wrote in his 1917 paper. As long as the magnitude of this new term on the geometry side of the equation was small enough, it would not alter the theory’s predictions for planetary motions in the solar system.
Einstein’s 1917 paper demonstrated the mathematical effectiveness of lambda (also called the “cosmological constant”) but did not say much about its physical interpretation. In another paper, published in 1918, he commented that lambda represented a negative mass density — it played “the role of gravitating negative masses which are distributed all over the interstellar space.” Negative mass would counter the attractive gravity and prevent all the matter in Einstein’s spherical finite universe from collapsing.
As everybody now knows, though, there is no danger of collapse, because the universe is not static to begin with, but rather is rapidly expanding. After Edwin Hubble had established such expansion, Einstein abandoned lambda as unnecessary (or at least, set it equal to zero in his equation). Others built on Einstein’s foundation to derive the math needed to make sense of Hubble’s discovery, eventually leading to the modern view of an expanding universe initiated by a Big Bang explosion.
But in the 1990s, astronomers discovered that the universe is not only expanding, it is expanding at an accelerating rate. Such acceleration requires a mysterious driving force, nicknamed “dark energy,” exerting negative pressure in space. Many experts believe Einstein’s cosmological constant, now interpreted as a constant amount of energy with negative pressure infusing all of space, is the dark energy’s true identity.
Einstein might not have been surprised by all of this. He realized that only time would tell whether his lambda would vanish to zero or play a role in the motions of the heavens. As he wrote in 1917 to the Dutch physicist-astronomer Willem de Sitter: “One day, our actual knowledge of the composition of the fixed-star sky, the apparent motions of fixed stars, and the position of spectral lines as a function of distance, will probably have come far enough for us to be able to decide empirically the question of whether or not lambda vanishes.”
Immune system cells may help your heart keep the beat. These cells, called macrophages, usually protect the body from invading pathogens. But a new study published April 20 in Cell shows that in mice, the immune cells help electricity flow between muscle cells to keep the organ pumping.
Macrophages squeeze in between heart muscle cells, called cardiomyocytes. These muscle cells rhythmically contract in response to electrical signals, pumping blood through the heart. By “plugging in” to the cardiomyocytes, macrophages help the heart cells receive the signals and stay on beat. Researchers have known for a couple of years that macrophages live in healthy heart tissue. But their specific functions “were still very much a mystery,” says Edward Thorp, an immunologist at Northwestern University’s Feinberg School of Medicine in Chicago. He calls the study’s conclusion that macrophages electrically couple with cardiomyocytes “paradigm shifting.” It highlights “the functional diversity and physiologic importance of macrophages, beyond their role in host defense,” Thorp says.
Matthias Nahrendorf, a cell biologist at Harvard Medical School, stumbled onto this electrifying find by accident.
Curious about how macrophages impact the heart, he tried to perform a cardiac MRI on a mouse genetically engineered to not have the immune cells. But the rodent’s heartbeat was too slow and irregular to perform the scan. These symptoms pointed to a problem in the mouse’s atrioventricular node, a bundle of muscle fibers that electrically connects the upper and lower chambers of the heart. Humans with AV node irregularities may need a pacemaker to keep their heart beating in time. In healthy mice, researchers discovered macrophages concentrated in the AV node, but what the cells were doing there was unknown. Isolating a heart macrophage and testing it for electrical activity didn’t solve the mystery. But when the researchers coupled a macrophage with a cardiomyocyte, the two cells began communicating electrically. That’s important, because the heart muscle cells contract thanks to electrical signals.
Cardiomyocytes have an imbalance of ions. While in the resting state, there are more positive ions outside the cell than inside, but when a cardiomyocyte receives an electrical signal from a neighboring heart cell, that distribution switches. This momentary change causes the cell to contract and send the signal on to the next cardiomyocyte.
Scientists previously thought that cardiomyocytes were capable of this electrical shift, called depolarization, on their own. But Nahrendorf and his team found that macrophages aid in the process. Using a protein, a macrophage hooks up to a cardiomyocyte. This protein directly connects the inside of these cells to each other, allowing macrophages to transfer positive charges, giving cardiomyocytes a boost kind of like with a jumper cable. This makes it easier for the heart cells to depolarize and trigger the heart contraction, Nahrendorf says.
“With the help of the macrophages, the conduction system becomes more reliable, and it is able to conduct faster,” he says.
Nahrendorf and colleagues found macrophages within the AV node in human hearts as well but don’t know if the cells play the same role in people. The next step is to confirm that role and explore whether or not the immune cells could be behind heart problems like arrhythmia, says Nahrendorf.
Like most moms and dads, my time in the post-baby throes of sleep deprivation is a hazy memory. But I do remember feeling instant rage upon hearing a popular piece of advice for how to get my little one some shut-eye: “sleep begets sleep.” The rule’s reasoning is unassailable: To get some sleep, my baby just had to get some sleep. Oh. So helpful. Thank you, lady in the post office and entire Internet.
So I admit to feeling some satisfaction when I came across a study that found an exception to the “sleep begets sleep” rule. The study quite reasonably suggests there is a finite amount of sleep to be had, at least for the 50 Japanese 19-month-olds tracked by researchers.
The researchers used activity monitors to record a week’s worth of babies’ daytime naps, nighttime sleep and activity patterns. The results, published June 9, 2016, in Scientific Reports, showed a trade-off between naps and night sleep. Naps came at the expense of night sleep: The longer the nap, the shorter the night sleep, the researchers found. And naps that stretched late into the afternoon seemed to push back bedtime.
In this study, naps didn’t affect the total amount of sleep each child got. Instead, the distribution of sleep across day and night changed. That means you probably can’t tinker with your toddler’s nap schedule without also tinkering with her nighttime sleep. In a way, that’s reassuring: It makes it harder to screw up the nap in a way that leads to a sleep-deprived child. If daytime sleep is lacking, your child will probably make up for it at night.
A sleeping child looks blissfully relaxed, but beneath that quiet exterior, the body is doing some incredible work. New concepts and vocabulary get stitched into the brain. The immune system hones its ability to bust germs. And limbs literally stretch. Babies grew longer in the four days right after they slept more than normal, scientists reported in Sleep in 2011. Scientists don’t yet know if this important work happens selectively during naps or night sleep.
Right now, both my 4-year-old and 2-year-old take post-lunch naps (and on the absolute best of days, those naps occur in glorious tandem). Their siestas probably push their bedtimes back a bit. But that’s OK with all of us. Long spring and summer days make it hard for my girls to go to sleep at 7:30 p.m. anyway. The times I’ve optimistically tried an early bedtime, my younger daughter insists I look out the window to see the obvious: “The sky is awake, Mommy.”
An elephant may be hundreds of times larger than a cat, but when it comes to pooping, it doesn’t take the elephant hundreds of times longer to heed nature’s call. In fact, both animals will probably get the job done in less than 30 seconds, a new study finds.
Humans would probably fit in that time frame too, says Patricia Yang, a mechanical engineering graduate student at the Georgia Institute of Technology in Atlanta. That’s because elephants, cats and people all excrete cylindrical poop. The size of all those animals varies, but so does the thickness of the mucus lining in each animal’s large intestine, so no matter the mammal, everything takes about the same time — an average of 12 seconds — to come out, Yang and her colleagues conclude April 25 in Soft Matter.
But the average poop time is not the real takeaway here (though it will make a fabulous answer to a question on Jeopardy one day). Previous studies on defecation have largely come from the world of medical research. “We roughly know how it happened, but not the physics of it,” says Yang.
Looking more closely at those physical properties could prove useful in a number of ways. For example, rats are often good models for humans in disease research, but they aren’t when it comes to pooping because rats are pellet poopers. (They’re not good models for human urination, either, because their pee comes out differently than ours, in high-speed droplets instead of a stream.)
Also, since the thickness of the mucus lining is dependent on animal size, it would be better to find a more human-sized stand-in. Such work could help researchers find new treatments for constipation and diarrhea, in which the mucus lining plays a key role, the researchers note.
Animal defecation may seem like an odd topic for a mechanical engineer to take on, but Yang notes that the principles of fluid dynamics apply inside the body and out. Her previous research includes a study on animal urination, finding that, as with pooping, the time it takes for mammals to pee also falls within a small window. (The research won her group an Ig Nobel Prize in 2015.)
And while many would find this kind of research disgusting, Yang does not. “Working with poop is not that bad, to be honest,” she says. “It’s not that smelly.” Plus, she gets to go to the zoo and aquarium for her research rather than be stuck in the lab. But the research does involve a lot of poop — and watching it fall. For the study, the researchers timed the how long it took for animals to defecate and calculated the velocity of the feces of 11 species. They filmed dogs at a park and elephants, giant pandas and warthogs at Zoo Atlanta. They also dug up 19 YouTube videos of mammals defecating. Surprisingly, there are a lot of those videos available, though not many were actually good for the research. “We wanted a complete event, from beginning to end,” Yang notes. Apparently not everyone interested in pooping animals bothers to capture a feces’ full fall.
The researchers also examined feces from dozens of mammal species. (They fall into two classes: Carnivores defecate “sinkers,” since their feces are full of heavy indigestible ingredients like fur and bones. Herbivores defecate less-dense “floaters.”) And they considered the thickness and viscosity of the mucus that lines mammals’ intestines and helps everything move along as well the rectal pressure that pushes the material. All this information went into a mathematical model of mammal defecation — which revealed the importance of the mucus lining.
Yang isn’t done with this line of research. The model she and her colleagues created applies only to mammals that poop like we do. There’s still the pellet poopers, like rats and rabbits, and wombats, whose feces look like rounded cubes. “I would like to complete the whole set,” she says. And, “if you’ve got a good team, it’s fun.”
A question flamingo researchers get asked all the time — why the birds stand on one leg — may need rethinking. The bigger puzzle may be why flamingos bother standing on two.
Balance aids built into the birds’ basic anatomy allow for a one-legged stance that demands little muscular effort, tests find. This stance is so exquisitely stable that a bird sways less to keep itself upright when it appears to be dozing than when it’s alert with eyes open, two Atlanta neuromechanists report May 24 in Biology Letters. “Most of us aren’t aware that we’re moving around all the time,” says Lena Ting of Emory University, who measures what’s called postural sway in standing people as well as in animals. Just keeping the human body vertical demands constant sensing and muscular correction for wavering. Even standing robots “are expending quite a bit of energy,” she says. That could have been the case for flamingos, she points out, since effort isn’t always visible. Ting and Young-Hui Chang of the Georgia Institute of Technology tested balance in fluffy young Chilean flamingos coaxed onto a platform attached to an instrument that measures how much they sway. Keepers at Zoo Atlanta hand-rearing the test subjects let researchers visit after feeding time in hopes of catching youngsters inclined toward a nap — on one leg on a machine. “Patience,” Ting says, was the key to any success in this experiment.
As a flamingo standing on one foot shifted to preen a feather or joust with a neighbor, the instrument tracked wobbles in the foot’s center of pressure, the spot where the bird’s weight focused. When a bird tucked its head onto its pillowy back and shut its eyes, the center of pressure made smaller adjustments (within a radius of 3.2 millimeters on average, compared with 5.1 millimeters when active). Museum bones revealed features of the skeleton that might enhance stability, but bones alone didn’t tell the researchers enough. Deceased Caribbean flamingos a zoo donated to science gave a better view. “The ‘ah-ha!’ moment was when I said, ‘Wait, let’s look at it in a vertical position,’” Ting remembers. All of a sudden, the bird specimen settled naturally into one-legged lollipop alignment.
In flamingo anatomy, the hip and the knee lie well up inside the body. What bends in the middle of the long flamingo leg is not a knee but an ankle (which explains why to human eyes a walking flamingo’s leg joint bends the wrong way). The bones themselves don’t seem to have a strict on-off locking mechanism, though Ting has observed bony crests, double sockets and other features that could facilitate stable standing.
The bird’s distribution of weight, however, looked important for one-footed balance. The flamingo’s center of gravity was close to the inner knee where bones started to form the long column to the ground, giving the precarious-looking position remarkable stability. The specimen’s body wasn’t as stable on two legs, the researchers found. Reinhold Necker of Ruhr University in Bochum, Germany, is cautious about calling one-legged stances an energy saver. “The authors do not consider the retracted leg,” says Necker, who has studied flamingos. Keeping that leg retracted could take some energy, even if easy balancing saves some, he proposes.
The new study takes an important step toward understanding how flamingos stand on one leg, but doesn’t explain why, comments Matthew Anderson, a comparative psychologist at St. Joseph’s University in Philadelphia. He’s found that more flamingos rest one-legged when temperatures drop, so he proposes that keeping warm might have something to do with it. The persistent flamingo question still stands.
Astronomers want you in on the search for the solar system’s ninth planet.
In the online citizen science project Backyard Worlds: Planet 9, space lovers can flip through space images and search for this potential planet as well as other far-off worlds awaiting discovery.
The images, taken by NASA’s Wide-field Infrared Survey Explorer satellite, offer a peek at a vast region of uncharted territory at the far fringes of the solar system and beyond. One area of interest is a ring of icy rocks past Neptune, known as the Kuiper belt. Possible alignments among the orbits of six objects out there hint that a ninth planet exerting its gravitational influence lurks in the darkness (SN: 7/23/16, p. 9). The WISE satellite may have imaged this distant world, and astronomers just haven’t identified it yet. Dwarf planets, free-floating worlds with no solar system to call home (SN: 4/4/15, p. 22) and failed stars may also be hidden in the images. The WISE satellite has snapped the entire sky several times, resulting in millions of images. With so many snapshots to sift through, researchers need extra eyes. At the Backyard Worlds website, success in spotting a new world requires sharp sight. You have to stare at what seems like thousands of fuzzy dots in a series of four false-color infrared images taken months to years apart and identify faint blobs that appear to move. Spot that movement and you may have found a new world.
But you can’t let blurry spots or objects moving in only a couple of the frames fool you: Image artifacts can look like convincing space objects. True detections come from slight shifts in the positions of red or whitish-blue dots. With so many dots to track, it’s best to break up an image into sections and then click through the four images section by section. This process can take hours. But think of the payoff — discovering a distant world no one has observed before.
Once you’ve marked any potential object of interest, the project’s astronomers take over. Jackie Faherty of the American Museum of Natural History in New York City and colleagues cross-reference the object’s coordinates with databases of celestial worlds. If the object does, in fact, appear to be a newbie, the team requests time on other telescopes to do follow-up. Those studies can reveal whether the object is a failed star or a planet.
So far, tens of thousands of citizen scientists have scoured images at Backyard Worlds. The team has identified five possible failed stars and had its first paper accepted for publication.
But there’s still much more to explore: The elusive Planet Nine might still be out there, disguised as a flash of dots.
Water swirling down a drain has exposed an elusive phenomenon long believed to appear in black holes.
Light waves scattering off a rotating black hole can bounce off with more energy than they came in with, by sapping some of the black hole’s rotational energy. But the effect, predicted in 1971 and known as rotational superradiance, is so weak that it would be extremely difficult to observe in a real black hole. So scientists had never seen rotational superradiance in action. Now, physicists report June 12 in Nature Physics that they’ve glimpsed the effect for the first time, in a black hole doppelgänger made with a vortex of water, similar to water swirling down a bathtub drain. “If you take a tennis ball and you throw it against a wall, you don’t expect it to come back with more energy,” says Silke Weinfurtner of the University of Nottingham in England, who led the study. “But when you throw something at a black hole, if it’s a rotating black hole, you can actually gain energy.”
To demonstrate the effect, the scientists created a swirl of water. “The fluid has to drain in a way that looks like a black hole,” says physicist Antonin Coutant, also at Nottingham. Surface ripples reach a point of no return where they are sucked into the vortex. That’s analogous to a black hole’s event horizon, the boundary from which no light can escape. Weinfurtner, Coutant and colleagues report that water waves scattering off the vortex got a superradiant boost: They were amplified by up to 14 percent on average, depending on the frequency and direction of the waves.
For obvious reasons, researchers can’t study a real black hole in a laboratory. If they could, “we’d all be in trouble,” says physicist Sam Dolan of the University of Sheffield in England, who was not involved with the study. A water vortex is the next best thing. The result, Dolan says, “gives us more confidence that our theories about black holes are correct.”
Although rotational superradiance is a weak effect in black holes, there may be opportunities to observe it, says physicist Vítor Cardoso of Instituto Superior Técnico in Lisbon, Portugal. Superradiance affects gravitational waves as well as light waves. Ripples in spacetime stirred up by merging black holes (SN Online: 6/1/17) should be slightly amplified if those black holes are spinning. That amplification could be observed by future ultrasensitive gravitational wave detectors.
