Hawk moths have a sweet solution to muscle damage.
Manduca sexta moths dine solely on nectar, but the sugary liquid does more than fuel their bodies. The insects convert some of the sugars into antioxidants that protect the moths’ hardworking muscles, researchers report in the Feb. 17 Science.
When animals expend a lot of energy, like hawk moths do as they rapidly beat their wings to hover at a flower, their bodies produce reactive molecules, which attack muscle and other cells. Humans and other animals eat foods that contain antioxidants that neutralize the harmful molecules. But the moths’ singular food source — nectar — has little to no antioxidants.
So the insects make their own. They send some of the nectar sugars through an alternative metabolic pathway to make antioxidants instead of energy, says study coauthor Eran Levin, an entomologist now at Tel Aviv University. Levin and colleagues say this mechanism may have allowed nectar-loving animals to evolve into powerful, energy-intensive fliers.
Immune system cells may help your heart keep the beat. These cells, called macrophages, usually protect the body from invading pathogens. But a new study published April 20 in Cell shows that in mice, the immune cells help electricity flow between muscle cells to keep the organ pumping.
Macrophages squeeze in between heart muscle cells, called cardiomyocytes. These muscle cells rhythmically contract in response to electrical signals, pumping blood through the heart. By “plugging in” to the cardiomyocytes, macrophages help the heart cells receive the signals and stay on beat. Researchers have known for a couple of years that macrophages live in healthy heart tissue. But their specific functions “were still very much a mystery,” says Edward Thorp, an immunologist at Northwestern University’s Feinberg School of Medicine in Chicago. He calls the study’s conclusion that macrophages electrically couple with cardiomyocytes “paradigm shifting.” It highlights “the functional diversity and physiologic importance of macrophages, beyond their role in host defense,” Thorp says.
Matthias Nahrendorf, a cell biologist at Harvard Medical School, stumbled onto this electrifying find by accident.
Curious about how macrophages impact the heart, he tried to perform a cardiac MRI on a mouse genetically engineered to not have the immune cells. But the rodent’s heartbeat was too slow and irregular to perform the scan. These symptoms pointed to a problem in the mouse’s atrioventricular node, a bundle of muscle fibers that electrically connects the upper and lower chambers of the heart. Humans with AV node irregularities may need a pacemaker to keep their heart beating in time. In healthy mice, researchers discovered macrophages concentrated in the AV node, but what the cells were doing there was unknown. Isolating a heart macrophage and testing it for electrical activity didn’t solve the mystery. But when the researchers coupled a macrophage with a cardiomyocyte, the two cells began communicating electrically. That’s important, because the heart muscle cells contract thanks to electrical signals.
Cardiomyocytes have an imbalance of ions. While in the resting state, there are more positive ions outside the cell than inside, but when a cardiomyocyte receives an electrical signal from a neighboring heart cell, that distribution switches. This momentary change causes the cell to contract and send the signal on to the next cardiomyocyte.
Scientists previously thought that cardiomyocytes were capable of this electrical shift, called depolarization, on their own. But Nahrendorf and his team found that macrophages aid in the process. Using a protein, a macrophage hooks up to a cardiomyocyte. This protein directly connects the inside of these cells to each other, allowing macrophages to transfer positive charges, giving cardiomyocytes a boost kind of like with a jumper cable. This makes it easier for the heart cells to depolarize and trigger the heart contraction, Nahrendorf says.
“With the help of the macrophages, the conduction system becomes more reliable, and it is able to conduct faster,” he says.
Nahrendorf and colleagues found macrophages within the AV node in human hearts as well but don’t know if the cells play the same role in people. The next step is to confirm that role and explore whether or not the immune cells could be behind heart problems like arrhythmia, says Nahrendorf.
Like most moms and dads, my time in the post-baby throes of sleep deprivation is a hazy memory. But I do remember feeling instant rage upon hearing a popular piece of advice for how to get my little one some shut-eye: “sleep begets sleep.” The rule’s reasoning is unassailable: To get some sleep, my baby just had to get some sleep. Oh. So helpful. Thank you, lady in the post office and entire Internet.
So I admit to feeling some satisfaction when I came across a study that found an exception to the “sleep begets sleep” rule. The study quite reasonably suggests there is a finite amount of sleep to be had, at least for the 50 Japanese 19-month-olds tracked by researchers.
The researchers used activity monitors to record a week’s worth of babies’ daytime naps, nighttime sleep and activity patterns. The results, published June 9, 2016, in Scientific Reports, showed a trade-off between naps and night sleep. Naps came at the expense of night sleep: The longer the nap, the shorter the night sleep, the researchers found. And naps that stretched late into the afternoon seemed to push back bedtime.
In this study, naps didn’t affect the total amount of sleep each child got. Instead, the distribution of sleep across day and night changed. That means you probably can’t tinker with your toddler’s nap schedule without also tinkering with her nighttime sleep. In a way, that’s reassuring: It makes it harder to screw up the nap in a way that leads to a sleep-deprived child. If daytime sleep is lacking, your child will probably make up for it at night.
A sleeping child looks blissfully relaxed, but beneath that quiet exterior, the body is doing some incredible work. New concepts and vocabulary get stitched into the brain. The immune system hones its ability to bust germs. And limbs literally stretch. Babies grew longer in the four days right after they slept more than normal, scientists reported in Sleep in 2011. Scientists don’t yet know if this important work happens selectively during naps or night sleep.
Right now, both my 4-year-old and 2-year-old take post-lunch naps (and on the absolute best of days, those naps occur in glorious tandem). Their siestas probably push their bedtimes back a bit. But that’s OK with all of us. Long spring and summer days make it hard for my girls to go to sleep at 7:30 p.m. anyway. The times I’ve optimistically tried an early bedtime, my younger daughter insists I look out the window to see the obvious: “The sky is awake, Mommy.”
An elephant may be hundreds of times larger than a cat, but when it comes to pooping, it doesn’t take the elephant hundreds of times longer to heed nature’s call. In fact, both animals will probably get the job done in less than 30 seconds, a new study finds.
Humans would probably fit in that time frame too, says Patricia Yang, a mechanical engineering graduate student at the Georgia Institute of Technology in Atlanta. That’s because elephants, cats and people all excrete cylindrical poop. The size of all those animals varies, but so does the thickness of the mucus lining in each animal’s large intestine, so no matter the mammal, everything takes about the same time — an average of 12 seconds — to come out, Yang and her colleagues conclude April 25 in Soft Matter.
But the average poop time is not the real takeaway here (though it will make a fabulous answer to a question on Jeopardy one day). Previous studies on defecation have largely come from the world of medical research. “We roughly know how it happened, but not the physics of it,” says Yang.
Looking more closely at those physical properties could prove useful in a number of ways. For example, rats are often good models for humans in disease research, but they aren’t when it comes to pooping because rats are pellet poopers. (They’re not good models for human urination, either, because their pee comes out differently than ours, in high-speed droplets instead of a stream.)
Also, since the thickness of the mucus lining is dependent on animal size, it would be better to find a more human-sized stand-in. Such work could help researchers find new treatments for constipation and diarrhea, in which the mucus lining plays a key role, the researchers note.
Animal defecation may seem like an odd topic for a mechanical engineer to take on, but Yang notes that the principles of fluid dynamics apply inside the body and out. Her previous research includes a study on animal urination, finding that, as with pooping, the time it takes for mammals to pee also falls within a small window. (The research won her group an Ig Nobel Prize in 2015.)
And while many would find this kind of research disgusting, Yang does not. “Working with poop is not that bad, to be honest,” she says. “It’s not that smelly.” Plus, she gets to go to the zoo and aquarium for her research rather than be stuck in the lab. But the research does involve a lot of poop — and watching it fall. For the study, the researchers timed the how long it took for animals to defecate and calculated the velocity of the feces of 11 species. They filmed dogs at a park and elephants, giant pandas and warthogs at Zoo Atlanta. They also dug up 19 YouTube videos of mammals defecating. Surprisingly, there are a lot of those videos available, though not many were actually good for the research. “We wanted a complete event, from beginning to end,” Yang notes. Apparently not everyone interested in pooping animals bothers to capture a feces’ full fall.
The researchers also examined feces from dozens of mammal species. (They fall into two classes: Carnivores defecate “sinkers,” since their feces are full of heavy indigestible ingredients like fur and bones. Herbivores defecate less-dense “floaters.”) And they considered the thickness and viscosity of the mucus that lines mammals’ intestines and helps everything move along as well the rectal pressure that pushes the material. All this information went into a mathematical model of mammal defecation — which revealed the importance of the mucus lining.
Yang isn’t done with this line of research. The model she and her colleagues created applies only to mammals that poop like we do. There’s still the pellet poopers, like rats and rabbits, and wombats, whose feces look like rounded cubes. “I would like to complete the whole set,” she says. And, “if you’ve got a good team, it’s fun.”
A question flamingo researchers get asked all the time — why the birds stand on one leg — may need rethinking. The bigger puzzle may be why flamingos bother standing on two.
Balance aids built into the birds’ basic anatomy allow for a one-legged stance that demands little muscular effort, tests find. This stance is so exquisitely stable that a bird sways less to keep itself upright when it appears to be dozing than when it’s alert with eyes open, two Atlanta neuromechanists report May 24 in Biology Letters. “Most of us aren’t aware that we’re moving around all the time,” says Lena Ting of Emory University, who measures what’s called postural sway in standing people as well as in animals. Just keeping the human body vertical demands constant sensing and muscular correction for wavering. Even standing robots “are expending quite a bit of energy,” she says. That could have been the case for flamingos, she points out, since effort isn’t always visible. Ting and Young-Hui Chang of the Georgia Institute of Technology tested balance in fluffy young Chilean flamingos coaxed onto a platform attached to an instrument that measures how much they sway. Keepers at Zoo Atlanta hand-rearing the test subjects let researchers visit after feeding time in hopes of catching youngsters inclined toward a nap — on one leg on a machine. “Patience,” Ting says, was the key to any success in this experiment.
As a flamingo standing on one foot shifted to preen a feather or joust with a neighbor, the instrument tracked wobbles in the foot’s center of pressure, the spot where the bird’s weight focused. When a bird tucked its head onto its pillowy back and shut its eyes, the center of pressure made smaller adjustments (within a radius of 3.2 millimeters on average, compared with 5.1 millimeters when active). Museum bones revealed features of the skeleton that might enhance stability, but bones alone didn’t tell the researchers enough. Deceased Caribbean flamingos a zoo donated to science gave a better view. “The ‘ah-ha!’ moment was when I said, ‘Wait, let’s look at it in a vertical position,’” Ting remembers. All of a sudden, the bird specimen settled naturally into one-legged lollipop alignment.
In flamingo anatomy, the hip and the knee lie well up inside the body. What bends in the middle of the long flamingo leg is not a knee but an ankle (which explains why to human eyes a walking flamingo’s leg joint bends the wrong way). The bones themselves don’t seem to have a strict on-off locking mechanism, though Ting has observed bony crests, double sockets and other features that could facilitate stable standing.
The bird’s distribution of weight, however, looked important for one-footed balance. The flamingo’s center of gravity was close to the inner knee where bones started to form the long column to the ground, giving the precarious-looking position remarkable stability. The specimen’s body wasn’t as stable on two legs, the researchers found. Reinhold Necker of Ruhr University in Bochum, Germany, is cautious about calling one-legged stances an energy saver. “The authors do not consider the retracted leg,” says Necker, who has studied flamingos. Keeping that leg retracted could take some energy, even if easy balancing saves some, he proposes.
The new study takes an important step toward understanding how flamingos stand on one leg, but doesn’t explain why, comments Matthew Anderson, a comparative psychologist at St. Joseph’s University in Philadelphia. He’s found that more flamingos rest one-legged when temperatures drop, so he proposes that keeping warm might have something to do with it. The persistent flamingo question still stands.
Astronomers want you in on the search for the solar system’s ninth planet.
In the online citizen science project Backyard Worlds: Planet 9, space lovers can flip through space images and search for this potential planet as well as other far-off worlds awaiting discovery.
The images, taken by NASA’s Wide-field Infrared Survey Explorer satellite, offer a peek at a vast region of uncharted territory at the far fringes of the solar system and beyond. One area of interest is a ring of icy rocks past Neptune, known as the Kuiper belt. Possible alignments among the orbits of six objects out there hint that a ninth planet exerting its gravitational influence lurks in the darkness (SN: 7/23/16, p. 9). The WISE satellite may have imaged this distant world, and astronomers just haven’t identified it yet. Dwarf planets, free-floating worlds with no solar system to call home (SN: 4/4/15, p. 22) and failed stars may also be hidden in the images. The WISE satellite has snapped the entire sky several times, resulting in millions of images. With so many snapshots to sift through, researchers need extra eyes. At the Backyard Worlds website, success in spotting a new world requires sharp sight. You have to stare at what seems like thousands of fuzzy dots in a series of four false-color infrared images taken months to years apart and identify faint blobs that appear to move. Spot that movement and you may have found a new world.
But you can’t let blurry spots or objects moving in only a couple of the frames fool you: Image artifacts can look like convincing space objects. True detections come from slight shifts in the positions of red or whitish-blue dots. With so many dots to track, it’s best to break up an image into sections and then click through the four images section by section. This process can take hours. But think of the payoff — discovering a distant world no one has observed before.
Once you’ve marked any potential object of interest, the project’s astronomers take over. Jackie Faherty of the American Museum of Natural History in New York City and colleagues cross-reference the object’s coordinates with databases of celestial worlds. If the object does, in fact, appear to be a newbie, the team requests time on other telescopes to do follow-up. Those studies can reveal whether the object is a failed star or a planet.
So far, tens of thousands of citizen scientists have scoured images at Backyard Worlds. The team has identified five possible failed stars and had its first paper accepted for publication.
But there’s still much more to explore: The elusive Planet Nine might still be out there, disguised as a flash of dots.
After an influenza infection, the nose recruits immune cells with long memories to keep watch for the virus, research with mice suggests.
For the first time, this type of immune cell — known as tissue resident memory T cells — has been found in the nose, researchers report June 2 in Science Immunology. Such nasal resident memory T cells may prevent flu from recurring. Future nasal spray vaccines that boost the number of these T cells in the nose might be an improvement over current flu shots, researchers say. It’s known that some T cell sentinels take up residence in specific tissues, including the brain, liver, intestines, skin and lungs. In most of these tissues, the resident memory T cells start patrolling after a localized infection. “They’re basically sitting there waiting in case you get infected with that pathogen again,” says Linda Wakim, an immunologist at the University of Melbourne in Australia. If a previous virus invades again, the T cells can quickly kill infected cells and make chemical signals, called cytokines, to call in other immune cells for reinforcement. These T cells can persist for years in most tissues.
It’s different in the lungs. There, resident memory T cells have shorter-term memories than ones that reside in other tissues, scientists have previously found. To see if all tissues in the respiratory tract have similarly forgetful immune cells, Wakim and colleagues tagged immune cells in mice and sprayed flu virus in the rodents’ noses. After infection, resident memory T cells settled into the nasal tissue. The researchers haven’t yet dissected any human noses, but it’s a pretty good bet they also contain resident memory T cells, Wakim says. Unlike in the lungs, the nose T cells had long memories, persisting for a least a year. “For mice, that’s quite a long time, almost a third of their life,” Wakim says. She doesn’t yet know why there’s a difference between nose and lung T cell memories, but finding out may enable researchers to boost lung T cell memory. Still, with nose T cells providing security, the lungs might not need much flu-fighting memory. Memory T cells that patrol only the upper respiratory tract could stop viruses from ever reaching the lungs, Wakim’s team found. An injection of virus under the skin didn’t produce any resident memory T cells in the respiratory tract. Those findings could mean that vaccines delivered via nasal spray instead of shots might stimulate memory T cell growth in the nose and could protect lungs from damage as well. A nasal spray called FluMist has had variable results in people. No one knows if that vaccine can produce nasal memory T cells. It’s not surprising to find that the nose has its own resident memory T cell security force, says Troy Randall, a pulmonary immunologist at the University of Alabama at Birmingham. “But it’s a good thing to know and certainly they’re the first to show it.”
The discovery may direct some research away from the lungs and toward the nose, Randall says. Future research should focus on how the resident memory T cells work with memory B cells that produce antibodies against viruses and bacteria, he suggests.
Water swirling down a drain has exposed an elusive phenomenon long believed to appear in black holes.
Light waves scattering off a rotating black hole can bounce off with more energy than they came in with, by sapping some of the black hole’s rotational energy. But the effect, predicted in 1971 and known as rotational superradiance, is so weak that it would be extremely difficult to observe in a real black hole. So scientists had never seen rotational superradiance in action. Now, physicists report June 12 in Nature Physics that they’ve glimpsed the effect for the first time, in a black hole doppelgänger made with a vortex of water, similar to water swirling down a bathtub drain. “If you take a tennis ball and you throw it against a wall, you don’t expect it to come back with more energy,” says Silke Weinfurtner of the University of Nottingham in England, who led the study. “But when you throw something at a black hole, if it’s a rotating black hole, you can actually gain energy.”
To demonstrate the effect, the scientists created a swirl of water. “The fluid has to drain in a way that looks like a black hole,” says physicist Antonin Coutant, also at Nottingham. Surface ripples reach a point of no return where they are sucked into the vortex. That’s analogous to a black hole’s event horizon, the boundary from which no light can escape. Weinfurtner, Coutant and colleagues report that water waves scattering off the vortex got a superradiant boost: They were amplified by up to 14 percent on average, depending on the frequency and direction of the waves.
For obvious reasons, researchers can’t study a real black hole in a laboratory. If they could, “we’d all be in trouble,” says physicist Sam Dolan of the University of Sheffield in England, who was not involved with the study. A water vortex is the next best thing. The result, Dolan says, “gives us more confidence that our theories about black holes are correct.”
Although rotational superradiance is a weak effect in black holes, there may be opportunities to observe it, says physicist Vítor Cardoso of Instituto Superior Técnico in Lisbon, Portugal. Superradiance affects gravitational waves as well as light waves. Ripples in spacetime stirred up by merging black holes (SN Online: 6/1/17) should be slightly amplified if those black holes are spinning. That amplification could be observed by future ultrasensitive gravitational wave detectors.
For the first time, researchers have watched relatively cool parcels of plasma speed away from the surface of the sun and off into space, all the while cocooned in a million-degree flare.
Shadia Habbal of the University of Hawaii in Honolulu and colleagues used a specially designed spectrometer to observe the eruption from Svalbard, Norway, during the March 2015 solar eclipse. The results, published online June 9 in Astrophysical Journal Letters, include measurements of the speed, temperature and composition of filaments of solar material streaming away from the sun — three features never measured simultaneously before. The data provide the first direct evidence of cooler solar material within an eruption and map its speed and trajectory, says Enrico Landi of the University of Michigan in Ann Arbor. “No instrument has ever been able to obtain these data.”
The sun’s surface is a roiling mass of hot ionized gas, or plasma, which is about a roasty 6,000° Celsius. But its corona, the wispy, halolike atmosphere that is visible during a solar eclipse, is superheated to millions of degrees. Scientists are still not sure how it gets so hot.Every so often, a huge, hot bubble of coronal plasma appears to burst off the sun’s surface in an eruption called a coronal mass ejection, or CME. These ejections send energetic charged particles hurtling into space at millions of miles per hour. When aimed at Earth, those particles can damage satellites and knock out power systems (SN Online: 4/9/12), so scientists want to understand CMEs to better predict them. The trouble is, it’s difficult to watch CMEs close to their origins. Sun-watching spacecraft block out the bulk of the sun’s light with a shield to avoid blinding their cameras. That gives spacecraft a constant view of the shimmering corona, but hides the sun’s surface.
The March 20, 2015, total solar eclipse over Svalbard gave Habbal’s team a rare view of the whole solar atmosphere because the moon and the sun appear almost the same size in the sky. “You can see things right from the solar surface out to several solar radii,” she says.
Her team brought a custom-built spectrometer the size of an airline-approved carry-on, designed by coauthor Adalbert Ding of the Technical University of Berlin. The spectrometer is sensitive to wavelengths of light emitted by iron atoms that have lost all but 11 or 14 of their electrons. Researchers can use those iron ions in the solar material to trace temperature: The hotter the solar plasma, the more electrons the iron has lost. As expected, coronal temperatures soared to 2 million or so degrees Celsius. But the team also saw some cooler blobs at a mere 20,000° C. Instead of losing their electrons to the heat and becoming ionized, these blobs maintained their cool.
Habbal thinks these are bright fingers of plasma called prominences, which had previously been observed stretching away from the sun before a CME.
“If you have an ice cube in a hot bath, it’s going to melt and evaporate,” Habbal says. “Here you have clusters of cool material that are enwrapped by very hot material. You would expect them to get ionized, but they didn’t.”
By measuring the solar material’s Doppler shift, or the change in wavelength as the material moved, the instrument could also clock its speed and direction. If the wavelength of the light appeared longer (or redder) in some places, that means the material was moving away from the observers. Shorter wavelength, or bluer light, indicated material moving toward them.
During the eclipse, material around the solar disk zoomed away at 100 to 1,500 kilometers per second. Such great speeds indicated that a CME erupted, and the direction suggested it was on the far side of the sun. Catching a CME during the short eclipse was a lucky coincidence.
“Lots of things about this experiment were just sheer luck,” Habbal says.
Cool inclusions have been spotted inside the hot corona before, but this is the first time they were seen fleeing the surface of the sun during a CME, Habbal says.
Prominences are thought to be associated with CMEs, and might even trigger their eruptions, but no one is sure how. Now that it’s possible to trace them from the solar surface out into space, researchers hope to spot more during the total eclipse as it crosses the United States in August (SN: 8/20/16, p. 14).
“If successful, it will be the dataset of a lifetime,” says Landi.
Hunter-gatherers who built and worshiped at one of the oldest known ritual centers in the world carved up human skulls in a style all their own.
At Turkey’s Göbekli Tepe site — where human activity dates to between around 11,600 and 10,000 years ago — people cut deep grooves in three human skulls and drilled a hole in at least one of them, say archaeologist Julia Gresky of the German Archaeological Institute in Berlin and colleagues. Ancient hunter-gatherers there practiced a previously unknown version of a “skull cult,” in which human skulls were ritually modified after death and then deposited together, Gresky’s team reports online June 28 in Science Advances.
Collections of human skulls modified in other ways have been found at several sites from around the same time. For instance, deliberately broken faces on skulls were unearthed at a Syrian settlement and may represent a form of punishment after death.
Seven excavated skull fragments enabled Gresky’s group to reconstruct the Göbekli Tepe skulls. These skulls of the recently deceased were carved for use in ceremonies to worship them as ancestors, the researchers propose. It’s also possible that the skull incisions marked deceased individuals who had been especially revered or reviled while alive.
A cord inserted through the hole drilled in one skull may have suspended that skull for display. Grooves probably ran from front to back on the skulls and possibly stabilized cords that held decorations of some kind.
Microscopic study of skull pieces from Göbekli Tepe indicates that grooves were cut with stone tools. A lack of healed bone on the edges of incisions suggests skull carving occurred shortly after death.
