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The planning of large-scale scientific facilities and basic research requires long-term perspective and more investment, said Wang Yifang, director of the Institute of High Energy Physics (IHEP) of Chinese Academy of Sciences (CAS), who is also a deputy to the 14th National People's Congress.

China has made remarkable achievements in the construction of large-scale scientific facilities after decades of development. If all projects planned in the 14th Five-Year Plan (2021-2025) are completed, China will have approximately 70 large scientific facilities, a number comparable to that of the US, Wang told the Global Times.

However, there is still a significant gap in terms of the investment scale for individual facility and the total investment scale compared to the US. Currently, China still lacks internationally leading specialized large scientific facilities, especially in the fields of particle physics, nuclear physics, and astronomy, he stressed.

"This puts us at a disadvantage compared to some other countries in certain areas, such as astronomical telescopes and particle accelerators. Therefore, I believe that in the future, we should focus on improving the quality of development rather than increasing the quantity of large scientific facilities in order to compete directly with advanced countries and strive to surpass them," Wang said.

"Without large scientific facilities, basic research would be just an idea on paper. We mustn't always be a recipient of knowledge, but should grow into a provider of knowledge and leader in global basic research," Wang said.

China has been paying more attention to strengthening basic research, as it is not only a cornerstone for achieving greater self-reliance and strength in science and technology, but the foundation for solving many bottleneck technologies. In the face of fierce international scientific and technological competition, Wang stressed that increasing funding for basic scientific research is a priority.

According to data from the National Bureau of Statistics, in 2022, the country's investment in basic research accounted for 6.57 percent of total research and development (R&D) spending, while the goal according to the 14th Five-Year Plan is 8 percent by 2025, which Wang said requires more efforts to realize.

Wang called for long-term perspective when planning research investment, looking ahead to the situation in 10, 15, or even 20 years.

Taking the construction of China's Circular Electron-Positron Collider (CEPC) as an example, we have to be clear that the construction period for the CEPC is 10 years. If we do not start now, China will lag behind others in this field in 10 years' time, Wang said.
A window to new physical world

The CEPC is a large international scientific facility proposed by the Chinese particle physics community in 2012. The project, to be hosted in China in a circular underground tunnel of approximately 100 kilometers in circumference, is a double-ring collider with electron and positron beams circulated in opposite directions in separate beam pipes, and the detectors are installed at two interaction points, according to the CAS.

The CEPC's "Technical Design Report" has gone through international review and was officially published in December, 2023. Being able to independently design such a large scientific facility demonstrates Chinese scientists' capabilities, according to Wang.

In the next step, the scientists will proceed with the engineering design and integrate the completed components, according to Wang. "We have completed the construction of a single prototype, and the next step is to figure out how to mass-produce individual products. In addition, we will continue to conduct in-depth research on some key technical details to ensure that our facility achieves optimal performance and cost-effectiveness."

It will take about three more years before the CEPC can begin actual construction, with the entire construction period lasting approximately 10 years, Wang noted.

The location for the CEPC has not yet been decided, according to Wang. "The ideal construction site should meet the following conditions: first, geological conditions, the CEPC should be built on intact and solid underground rock. Second, the construction site of the CEPC should consider factors such as transportation conditions, humanistic environment and educational environment, as the CEPC will serve as an international research base in the future, it should have an open environment that attracts talents from various countries and regions to work there," Wang explained.

The CEPC project will reportedly cost 36 billion yuan ($4.9 billion) and will have a circumference of 100 kilometers, with center-mass energy of up to 240 giga electron-volts, both setting a world record.

The goal of the CEPC is to build a high-luminosity Higgs factory. The existing standard model of physics is imperfect and has many inconsistencies, we need to find the fundamental reasons for them and Higgs is believed by global physicists to be the best window to find these loopholes, Wang explained.

In terms of controversies over the project, Wang responded that "in terms of science, I think we have made relevant issues very clear; in terms of techniques, we have proven through a large amount of experimental data, prototypes and the high-energy synchrotron radiation light source we are building in Huairou, that we have the ability to design and construct such a large scientific facility."

As to the cost, Wang stressed that CEPC is a facility to be used by the whole community of high-energy physics. There will be thousands of scientists working for decades. Considering this, the average investment per scientist per year would be far from being high. "Thousands of high-energy physicists are willing to invest all their energy, funds and time in a single facility, the average cost will not be higher than that of other research fields," he said.
'It relies on human intelligence to drive scientific progress'

In recent years, the rapid development of artificial intelligence (AI) technologies and products have created a stir around the world, especially after the release of the up-to-one-minute-long realistic videos created by the text-to-video AI generator Sora in early February.

According to OpenAI's explainer, Sora is capable of generating complex scenes with accurate details, including multiple characters, specific types of movements, themes and backgrounds. It understands not only what the user requests in the prompts, but also how these things exist in the physical world.

In fact, there has been a long-existing debate over whether AI can really understand - rather than imitate - physical laws and whether they can help discover new laws.

As a top physicist in China, Wang said it may be difficult for AI to break this barrier.

The most fundamental cornerstone of AI technology is the ability to predict the future to some extent through learning, but this so-called prediction is linear and based on existing knowledge. However, physics rules, especially new discoveries and concepts, are not simple extension of existing knowledge and data, Wang said.

After all it still requires scientific research and human intelligence to drive scientific progress, Wang said.

Multiple political and civilian groups on Taiwan island on Tuesday initiated a peace declaration signing activity, urging the Democratic Progressive Party (DPP) authorities to adhere to the one-China principle, and stop compromising cross-Straits relations or forcing the people on the island to face the existential choice between war and peace. 

The Cross-Strait Peaceful Development Forum, together with more than 60 pro-reunification groups, including the Labor Party of Taiwan, the Reunification Alliance Party, and the Blue Sky Action Alliance, organized the Tuesday activity. 

The initiators of the Tuesday activity urged Lai Ching-te, who will take office as the regional leader of the Taiwan island on May 20, to adhere to the one-China principle, respond to the majority of Taiwan people's advocacy for peace, take the window of goodwill opened by the mainland, and seize the opportunity to defuse the cross-Straits crisis, according to a release sent to the Global Times by the initiators.

The DPP authorities' eight-year policy of hostility toward the mainland has continuously worsened cross-Straits relations, with the situation across the Taiwan Straits becoming increasingly tense, forcing the Taiwan people to face the existential choice between war or peace, stability or turmoil, prosperity or decline, Wang Wu-lang, secretary-general of the Cross-Straits Peace Forum, told the Global Times on Tuesday. 

With the situation of the Taiwan Straits becoming more perilous and people feeling insecure, Lai won't easily abandon the stance and advocacy for "Taiwan independence," said Wang, noting that his stance completely disregards the survival and development interest of the vast majority of the Taiwan people.

The DPP authorities may continue their strategy of rejecting reunification and seeking independence by relying on the US to pursue political gains, Wang said, noting that Lai may taunt the "promises" which the US and some Western countries made to Taiwan to continue to fool the public. 

Aside from urging Lai to adhere to the one-China principle in his speech on May 20, the initiators of the Tuesday activity also put forward six appeals to urge the DPP authorities to resume various aspects of social, economic, and cultural exchanges and cooperation across the Straits, safeguard the legitimate rights of people from both sides of the Straits to communicate and interact.

They also oppose any arms purchases and cross-Straits policies that treat the mainland as a hostile entity, and required the DPP authorities to provide Taiwan's youth with a fair historical perspective and an environment conducive to cross-Straits peace and development.

Lai and those who seek "Taiwan independence" are going against the historical trend of the rejuvenation of the Chinese nation, and their path will not succeed, said Wang, calling for Taiwan people to unite and promote cross-Straits stability. 

The Central Commission for Discipline Inspection (CCDI) of the Communist Party of China (CPC) and the National Commission of Supervision (NCS), the country’s top anti-graft body, has pledged to intensify scrutiny in areas including finance, state-owned enterprises (SOEs), healthcare, grain procurement and sale, rural revitalization, tobacco, sports, statistics and more.

Special efforts will be carried out to tackle industrial, systemic and regional corruption cases, and effectively prevent and defuse systemic risks, according to an article released on the CCDI and NCS’ website on Monday.

The article highlighted that in order to decisively win the protracted and tough battle against corruption, it is imperative to consistently maintain a “high-pressure stance” and never relent in the determination to punish wrongdoing.

According to a five-year work plan of the Central Anti-Corruption Coordination Group from 2023 to 2027, the anti-corruption work will be further expanded to the primary level, with harsh punishments for misconduct including embezzlement, illegal possession and misappropriation, as well as ways to solicit bribes.

A total of 405,000 officials at all levels were punished over the first nine months of 2023, of whom 34 of were senior officials at provincial or ministerial levels, per data from the CCDI and NCS.

In recent years, the financial sector has been a focal point for anti-corruption efforts. In 2023, at least 101 individuals in the financial field were put under investigation, according to media reports.

Notably, the list includes senior officials like Liu Liange, former Party chief and president of the Bank of China, Zhou Qingyu, a former vice president of China Development Bank, and Li Xiaopeng, former Party chief and chairman of China Everbright Group.

Out of the 101 individuals under investigation, 74 are from the banking sector, 12 from regulatory authorities, seven from insurance institutions, two from financial groups, one from a securities institution, and five from other financial organizations, domestic news site Thepaper.cn reported.

The high-intensity anti-corruption campaign continues into the beginning of 2024, with the latest busted case involving Wang Yongsheng, former deputy president of China Development Bank, who was expelled from the CPC for severe violations of Party discipline and the law, the country's top anti-graft body said on Friday.

The Philadelphia Orchestra, a renowned US art group which embarked on a historic art icebreaking trip 1973, is scheduled to perform on Friday night in Beijing with China National Symphony Orchestra as an opening episode for a tour which will also make stops in Tianjin, Shanghai and Suzhou.

As the first American art group to perform in the People's Republic of China half a century ago, the orchestra has returned to China for their 12th visit after unexpected hiatus due to the pandemic.

"The pandemic is not the fault of either government, but has separated us," US ambassador to China Nicholas Burns said on Thursday addressing a reception commemorating the half century of friendship marked by music.

Both China and the US agree that we are in need of greater connections between the peoples, as the ballast of any relationship between two great countries is the people, Burns said.

The reception is hosted by the Chinese People's Association for Friendship with Foreign Countries (CPAFFC). Yang Wanming, president of the CPAFFC, sensed American friends' concerns about the recent China-US relations through communication with them.

"Yet I have also felt the strong desire of various sectors in the US, especially from the people and local communities, to improve the current situation and the earnest hope for stable and healthy development of the bilateral relationship," Yang said in his speech on Thursday.

Despite many complications in the US-China relationship, the people of China and the US have a lot in common and need to come together, Burns told the Global Times.

"We need more of this [music exchanges], and we need sports diplomacy," the ambassador said, citing his latest experience of watching Shanghai Sharks, with American players, in basketball game with Beijing Ducks on Sunday.

Burns expressed his hope that more tourists, students and businesspeople could go back and forth between China and the US, as people are an integral part of any diplomatic relationship.

Matías Tarnopolsky, the orchestra's president and CEO, said that music has the power to connect and to build bridges.

"It has been our privilege to contribute in a meaningful way to US-China understanding and connection for the past half-century. We hope that our music-making will continue to build bridges between our people and cultures for another 50 years," Tarnopolsky said.

Violinist Davyd Booth, 74, was on the historic tour in 1973 and every China visit since then. He shared with the Global Times in an earlier interview his vivid memories of the first tour and the development he has witnessed over the past 50 years.

"The friendship between the two countries bridges all sorts of gaps as music brings everyone together. Now we have many Chinese members in the Philadelphia Orchestra. China is really a part of us," said Booth.
Musicians from the Philadelphia Orchestra performed excerpts from "Flax and Charlock" Fantasie Quartet, an excerpt from "Lan Hua Hua," adapted from traditional Chinese folk music that originated in Northwest China's Shaanxi Province.

They also cooperated with children from Beijing Philharmonic Choir to perform the traditional Chinese song "Jasmine Flower."

It is hoped that the children, and more people of younger generations, will inherit the cause of China-US exchanges and carry on the mission of friendship for the next half century and beyond, a reception attendee told the Global Times.

For some poison dart frogs, gaining resistance to one of their own toxins came with a price.

The genetic change that gives one group of frogs immunity to a particularly lethal toxin also disrupts a key chemical messenger in the brain. But the frogs have managed to sidestep the potentially damaging side effect through other genetic tweaks, researchers report in the Sept. 22 Science.

While other studies have identified genetic changes that give frogs resistance to particular toxins, this study “lets you look under the hood” to see the full effects of those changes and how the frogs are compensating, says Butch Brodie, an evolutionary biologist at the University of Virginia in Charlottesville who wasn’t involved in the research.
Many poison dart frogs carry cocktails of toxic alkaloid molecules in their skin as a defense against predators (SN Online: 3/24/14). These toxins, picked up through the frogs’ diets, vary by species. Here, researchers studied frogs that carry epibatidine, a substance so poisonous that just a few millionths of a gram can kill a mouse.

Previous studies have shown that poisonous frogs have become resistant to the toxins the amphibians carry by messing with the proteins that these toxins bind to in the body. Switching out certain protein building blocks, or amino acids, changes the shape of the protein, which can prevent toxins from latching on. But making that change could have unintended side effects, too, says study coauthor Rebecca Tarvin, an evolutionary biologist at the University of Texas at Austin.

For example, the toxin epibatidine binds to proteins that are usually targeted by acetylcholine, a chemical messenger that’s necessary for normal brain function. So Tarvin and her colleagues looked at how this acetylcholine receptor protein differed between poison frog species that are resistant to epibatidine and some of their close relatives that aren’t.
Identifying differences between the frogs in the receptor protein’s amino acids allowed researchers to systematically test the effects of each change. To do so, the scientists put the genetic instructions for the same protein in humans, who aren’t resistant to epibatidine, into frog eggs. The researchers then replaced select amino acids in the human code with different poison frog substitutions to find an amino acid “switch” that would make the resulting receptor protein resistant to epibatidine.

But epibatidine resistance wasn’t a straightforward deal, it turned out. “We noticed that replacing one of those amino acids in the human [protein] made it resistant to epibatidine, but also affected its interaction with acetylcholine,” says study coauthor Cecilia Borghese, a neuropharmacologist also at the University of Texas at Austin. “Both are binding in the exact same region of the protein. It’s a very delicate situation.” That is, the amino acid change that made the receptor protein resistant to epibatidine also made it harder for acetylcholine to attach, potentially impeding the chemical messenger’s ability to do its job.

But the frogs themselves don’t seem impaired. That’s because other amino acid replacements elsewhere in the receptor protein appear to have compensated, Borghese and Tarvin found, creating a protein that won’t let the toxin latch on, but that still responds normally to acetylcholine.

The resistance-giving amino acid change appears to have evolved three separate times in poison frogs, Tarvin says. Three different lineages of the frogs have resistance to the poison, and all of them got that immunity by flipping the same switch. But the amino acid changes that bring back a normal acetylcholine response aren’t the same across those three groups.

“It’s a cool convergence that these other switches weren’t identical, but they all seem to recover that function,” Brodie says.

Two days before plunging into Saturn, the Cassini spacecraft took one last look around the planet it had orbited for more than 13 years.

The view of Saturn above, released November 21, is actually made from 42 images that have been stitched together. Six moons — Enceladus, Epimetheus, Janus, Mimas, Pandora and Prometheus — are faintly visible as dots surrounding the gas giant (see the annotated image below). Cassini was about 1.1 million kilometers away from Saturn when it took the images on September 13. The whole observation took a little over two hours.

On September 11, Cassini set itself on a collision course with Saturn, and on September 15, the probe ended its mission by burning up in Saturn’s atmosphere, taking data all the way down.

Wikipedia: The settler of dinnertime disputes and the savior of those who cheat on trivia night. Quick, what country has the Nile’s headwaters? What year did Gershwin write “Rhapsody in Blue”? Wikipedia has the answer to all your burning trivia questions — including ones about science.

With hundreds of thousands of scientific entries, Wikipedia offers a quick reference for the molecular formula of Zoloft, who the inventor of the 3-D printer is and the fact that the theory of plate tectonics is only about 100 years old. The website is a gold mine for science fans, science bloggers and scientists alike. But even though scientists use Wikipedia, they don’t tend to admit it. The site rarely ends up in a paper’s citations as the source of, say, the history of the gut-brain axis or the chemical formula for polyvinyl chloride.
But scientists are browsing Wikipedia just like everyone else. A recent analysis found that Wikipedia stays up-to-date on the latest research — and vocabulary from those Wikipedia articles finds its way into scientific papers. The results don’t just reveal the Wiki-habits of the ivory tower. They also show that the free, widely available information source is playing a role in research progress, especially in poorer countries.

Teachers in middle school, high school and college drill it in to their students: Wikipedia is not a citable source. Anyone can edit Wikipedia, and articles can change from day to day — sometimes by as little as a comma, other times being completely rewritten overnight. “[Wikipedia] has a reputation for being untrustworthy,” says Thomas Shafee, a biochemist at La Trobe University in Melbourne, Australia.

But those same teachers — even the college professors — who warn students away from Wikipedia are using the site themselves. “Academics use Wikipedia all the time because we’re human. It’s something everyone is doing,” says Doug Hanley, a macroeconomist at the University of Pittsburgh.

And the site’s unreliable reputation may be unwarranted. Wikipedia is not any less consistent than Encyclopedia Britannica, a 2005 Nature study showed (a conclusion that the encyclopedia itself vehemently objected to). Citing it as a source, however, is still a bridge too far. “It’s not respected like academic resources,” Shafee notes.
Academic science may not respect Wikipedia, but Wikipedia certainly loves science. Of the roughly 5.5 million articles, half a million to a million of them touch on scientific topics. And constant additions from hundreds of thousands of editors mean that entries can be very up to date on the latest scientific literature.

How recently published findings affect Wikipedia is easy to track. They’re cited on Wikipedia, after all. But does the relationship go the other way? Do scientific posts on Wikipedia worm their way into the academic literature, even though they are never cited? Hanley and his colleague Neil Thompson, an innovation scholar at MIT, decided to approach the question on two fronts.

First, they determined the 1.1 million most common scientific words in published articles from the scientific publishing giant Elsevier. Then, Hanley and Thompson examined how often those same words were added to or deleted from Wikipedia over time, and cited in the research literature. The researchers focused on two fields, chemistry and econometrics — a new area that develops statistical tests for economics.

There was a clear connection between the language in scientific papers and the language on Wikipedia. “Some new topic comes up and it gets exciting, it will generate a new Wikipedia page,” Thompson notes. The language on that new page was then connected to later scientific work. After a new entry was published, Hanley and Thompson showed, later scientific papers contained more language similar to the Wikipedia article than to papers in the field published before the new Wikipedia entry. There was a definite association between the language in the Wikipedia article and future scientific papers.

But was Wikipedia itself the source of that language? This part of the study can’t answer that. It only observes words increasing together in two different spaces. It can’t prove that scientists were reading Wikipedia and using it in their work.

So the researchers created new Wikipedia articles from scratch to find out if the language in them affected the scientific literature in return. Hanley and Thompson had graduate students in chemistry and in econometrics write up new Wikipedia articles on topics that weren’t yet on the site. The students wrote 43 chemistry articles and 45 econometrics articles. Then, half of the articles in each set got published to Wikipedia in January 2015, and the other half were held back as controls. The researchers gave the articles three months to percolate through the internet. Then they examined the next six months’ worth of published scientific papers in those fields for specific language used in the published Wikipedia entries, and compared it to the language in the entries that never got published.

In chemistry, at least, the new topics proved popular. Both the published and control Wikipedia page entries had been selected from graduate level topics in chemistry that weren’t yet covered on Wikipedia. They included entries such as the synthesis of hydrastine (the precursor to a drug that stops bleeding). People were interested enough to view the new articles on average 4,400 times per month.

The articles’ words trickled into to the scientific literature. In the six months after publishing, the entries influenced about 1 in 300 words in the newly published papers in that chemical discipline. And scientific papers on a topic covered in Wikipedia became slightly more like the Wikipedia article over time. For example, if chemists wrote about the synthesis of hydrastine — one of the new Wikipedia articles — published scientific papers more often used phrases like “Passarini reaction,” a term used in the Wikipedia entry. But if an article never went on to Wikipedia, the scientific papers published on the topic didn’t become any more similar to the never-published article (which could have happened if the topics were merely getting more popular). Hanley and Thompson published a preprint of their work to the Social Science Research Network on September 26.

Unfortunately, there was no number of Wikipedia articles that could make econometrics happen. “We wanted something on the edge of a discipline,” Thompson says. But it was a little too edgy. The new Wikipedia entries in that field got one-thirtieth of the views that chemistry articles did. Thompson and Hanley couldn’t get enough data from the articles to make any conclusions at all. Better luck next time, econometrics.

The relationship between Wikipedia entries and the scientific literature wasn’t the same in all regions. When Hanley and Thompson broke the published scientific papers down by the gross domestic product of their countries of origin, they found that Wikipedia articles had a stronger effect on the vocabulary in scientific papers published by scientists in countries with weaker economies. “If you think about it, if you’re a relatively rich country, you have access at your institution to a whole list of journals and the underlying scientific literature,” Hanley notes. Institutions in poorer countries, however, may not be able to afford expensive journal subscriptions, so scientists in those countries may rely more heavily on publicly available sources like Wikipedia.

The Wikipedia study is “excellent research design and very solid analysis,” says Heather Ford, who studies digital politics at the University of Leeds in England. “As far as I know, this is the first paper that attributes a strong link between what is on Wikipedia and the development of science.” But, she says, this is only within chemistry. The influence may be different in different fields.

“It’s addressing a question long in people’s minds but difficult to pin down and prove,” says Shafee. It’s a link, but tracking language, he explains, isn’t the same as finding out how ideas and concepts were moving from Wikipedia into the ivory tower. “It’s a real cliché to say more research is needed, but I think in this case it’s probably true.”

Hanley and Thompson would be the first to agree. “I think about this as a first step,” Hanley says. “It’s showing that Wikipedia is not just a passive resource, it also has an effect on the frontiers of knowledge.”

It’s a good reason for scientists get in and edit entries within their expertise, Thompson notes. “This is a big resource for science and I think we need to recognize that,” Thompson says. “There’s value in making sure the science on Wikipedia is as good and complete as possible.” Good scientific entries might not just settle arguments. They might also help science advance. After all, scientists are watching, even if they won’t admit it.